The origin, transmission and clinical therapies on coronavirus disease 2019 (COVID-19) outbreak – an update on the status
Identifieur interne : 000240 ( Main/Exploration ); précédent : 000239; suivant : 000241The origin, transmission and clinical therapies on coronavirus disease 2019 (COVID-19) outbreak – an update on the status
Auteurs : Yan-Rong Guo ; Qing-Dong Cao ; Zhong-Si Hong ; Yuan-Yang Tan ; Shou-Deng Chen ; Hong-Jun Jin ; Kai-Sen Tan [Singapour] ; De-Yun Wang [Singapour] ; Yan YanSource :
- Military Medical Research [ 2095-7467 ] ; 2020.
Descripteurs français
- KwdFr :
- Adulte, Adulte d'âge moyen, Animaux, Chine (épidémiologie), Chiroptera, Coronavirus du syndrome respiratoire du Moyen-Orient (génétique), Coronavirus du syndrome respiratoire du Moyen-Orient (pathogénicité), Diarrhée (étiologie), Fatigue (étiologie), Femelle, Fièvre (étiologie), Flambées de maladies, Humains, Infections à coronavirus (), Infections à coronavirus (diagnostic), Infections à coronavirus (transmission), Infections à coronavirus (épidémiologie), Mâle, Peptidyl-Dipeptidase A, Pneumopathie virale (), Pneumopathie virale (diagnostic), Pneumopathie virale (transmission), Pneumopathie virale (épidémiologie), Protéines de l'enveloppe virale, Réplication virale, Réservoirs d'agents pathogènes, Sujet âgé, Toux (étiologie), Virulence, Virus du SRAS (génétique), Virus du SRAS (pathogénicité).
- MESH :
- diagnostic : Infections à coronavirus, Pneumopathie virale.
- génétique : Coronavirus du syndrome respiratoire du Moyen-Orient, Virus du SRAS.
- pathogénicité : Coronavirus du syndrome respiratoire du Moyen-Orient, Virus du SRAS.
- épidémiologie : Chine, Infections à coronavirus, Pneumopathie virale.
- étiologie : Diarrhée, Fatigue, Fièvre, Toux.
- Adulte, Adulte d'âge moyen, Animaux, Chiroptera, Femelle, Flambées de maladies, Humains, Infections à coronavirus, Mâle, Peptidyl-Dipeptidase A, Pneumopathie virale, Protéines de l'enveloppe virale, Réplication virale, Réservoirs d'agents pathogènes, Sujet âgé, Virulence.
- Wicri :
- geographic : République populaire de Chine.
English descriptors
- KwdEn :
- Adult, Aged, Alphacoronavirus (genetics), Animals, Betacoronavirus (genetics), Betacoronavirus (pathogenicity), China (epidemiology), Chiroptera, Coronavirus Infections (diagnosis), Coronavirus Infections (epidemiology), Coronavirus Infections (therapy), Coronavirus Infections (transmission), Cough (etiology), Diarrhea (etiology), Disease Outbreaks, Disease Reservoirs, Fatigue (etiology), Female, Fever (etiology), Humans, Male, Middle Aged, Middle East Respiratory Syndrome Coronavirus (genetics), Middle East Respiratory Syndrome Coronavirus (pathogenicity), Peptidyl-Dipeptidase A, Pneumonia, Viral (diagnosis), Pneumonia, Viral (epidemiology), Pneumonia, Viral (therapy), Pneumonia, Viral (transmission), SARS Virus (genetics), SARS Virus (pathogenicity), Viral Envelope Proteins, Virulence, Virus Replication.
- MESH :
- chemical : Peptidyl-Dipeptidase A, Viral Envelope Proteins.
- geographic , epidemiology : China.
- diagnosis : Coronavirus Infections, Pneumonia, Viral.
- epidemiology : Coronavirus Infections, Pneumonia, Viral.
- etiology : Cough, Diarrhea, Fatigue, Fever.
- genetics : Alphacoronavirus, Betacoronavirus, Middle East Respiratory Syndrome Coronavirus, SARS Virus.
- pathogenicity : Betacoronavirus, Middle East Respiratory Syndrome Coronavirus, SARS Virus.
- therapy : Coronavirus Infections, Pneumonia, Viral.
- transmission : Coronavirus Infections, Pneumonia, Viral.
- Adult, Aged, Animals, Chiroptera, Disease Outbreaks, Disease Reservoirs, Female, Humans, Male, Middle Aged, Virulence, Virus Replication.
Abstract
An acute respiratory disease, caused by a novel coronavirus (SARS-CoV-2, previously known as 2019-nCoV), the coronavirus disease 2019 (COVID-19) has spread throughout China and received worldwide attention. On 30 January 2020, World Health Organization (WHO) officially declared the COVID-19 epidemic as a public health emergency of international concern. The emergence of SARS-CoV-2, since the severe acute respiratory syndrome coronavirus (SARS-CoV) in 2002 and Middle East respiratory syndrome coronavirus (MERS-CoV) in 2012, marked the third introduction of a highly pathogenic and large-scale epidemic coronavirus into the human population in the twenty-first century. As of 1 March 2020, a total of 87,137 confirmed cases globally, 79,968 confirmed in China and 7169 outside of China, with 2977 deaths (3.4%) had been reported by WHO. Meanwhile, several independent research groups have identified that SARS-CoV-2 belongs to β-coronavirus, with highly identical genome to bat coronavirus, pointing to bat as the natural host. The novel coronavirus uses the same receptor, angiotensin-converting enzyme 2 (ACE2) as that for SARS-CoV, and mainly spreads through the respiratory tract. Importantly, increasingly evidence showed sustained human-to-human transmission, along with many exported cases across the globe. The clinical symptoms of COVID-19 patients include fever, cough, fatigue and a small population of patients appeared gastrointestinal infection symptoms. The elderly and people with underlying diseases are susceptible to infection and prone to serious outcomes, which may be associated with acute respiratory distress syndrome (ARDS) and cytokine storm. Currently, there are few specific antiviral strategies, but several potent candidates of antivirals and repurposed drugs are under urgent investigation. In this review, we summarized the latest research progress of the epidemiology, pathogenesis, and clinical characteristics of COVID-19, and discussed the current treatment and scientific advancements to combat the epidemic novel coronavirus.
Url:
DOI: 10.1186/s40779-020-00240-0
PubMed: 32169119
PubMed Central: 7068984
Affiliations:
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Le document en format XML
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Biomedical Imaging and Guangdong Provincial Engineering Research Center of Molecular Imaging, Zhuhai, 519000 Guangdong China</nlm:aff><wicri:noCountry code="subfield">519000 Guangdong China</wicri:noCountry></affiliation></author><author><name sortKey="Chen, Shou Deng" sort="Chen, Shou Deng" uniqKey="Chen S" first="Shou-Deng" last="Chen">Shou-Deng Chen</name><affiliation><nlm:aff id="Aff1">Guangdong Provincial Key Laboratory of Biomedical Imaging and Guangdong Provincial Engineering Research Center of Molecular Imaging, Zhuhai, 519000 Guangdong China</nlm:aff><wicri:noCountry code="subfield">519000 Guangdong China</wicri:noCountry></affiliation></author><author><name sortKey="Jin, Hong Jun" sort="Jin, Hong Jun" uniqKey="Jin H" first="Hong-Jun" last="Jin">Hong-Jun Jin</name><affiliation><nlm:aff id="Aff1">Guangdong Provincial Key Laboratory of Biomedical Imaging and Guangdong Provincial Engineering Research Center of Molecular Imaging, Zhuhai, 519000 Guangdong China</nlm:aff><wicri:noCountry code="subfield">519000 Guangdong China</wicri:noCountry></affiliation></author><author><name sortKey="Tan, Kai Sen" sort="Tan, Kai Sen" uniqKey="Tan K" first="Kai-Sen" last="Tan">Kai-Sen Tan</name><affiliation wicri:level="1"><nlm:aff id="Aff4"><institution-wrap><institution-id institution-id-type="GRID">grid.4280.e</institution-id><institution-id institution-id-type="ISNI">0000 0001 2180 6431</institution-id><institution>Department of Otolaryngology, Yong Loo Lin School of Medicine,</institution><institution>National University of Singapore, National University Health System,</institution></institution-wrap>Singapore, 119228 Singapore</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea>Singapore</wicri:regionArea></affiliation></author><author><name sortKey="Wang, De Yun" sort="Wang, De Yun" uniqKey="Wang D" first="De-Yun" last="Wang">De-Yun Wang</name><affiliation wicri:level="1"><nlm:aff id="Aff4"><institution-wrap><institution-id 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institution-id-type="GRID">grid.452859.7</institution-id><institution>Center for Interventional Medicine,</institution><institution>the Fifth Affiliated Hospital, Sun Yat-Sen University,</institution></institution-wrap>Zhuhai, 519000 Guangdong China</nlm:aff><wicri:noCountry code="subfield">519000 Guangdong China</wicri:noCountry></affiliation></author></analytic><series><title level="j">Military Medical Research</title><idno type="ISSN">2095-7467</idno><idno type="eISSN">2054-9369</idno><imprint><date when="2020">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Alphacoronavirus (genetics)</term><term>Animals</term><term>Betacoronavirus (genetics)</term><term>Betacoronavirus (pathogenicity)</term><term>China (epidemiology)</term><term>Chiroptera</term><term>Coronavirus Infections (diagnosis)</term><term>Coronavirus Infections (epidemiology)</term><term>Coronavirus Infections (therapy)</term><term>Coronavirus Infections (transmission)</term><term>Cough (etiology)</term><term>Diarrhea (etiology)</term><term>Disease Outbreaks</term><term>Disease Reservoirs</term><term>Fatigue (etiology)</term><term>Female</term><term>Fever (etiology)</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Middle East Respiratory Syndrome Coronavirus (genetics)</term><term>Middle East Respiratory Syndrome Coronavirus (pathogenicity)</term><term>Peptidyl-Dipeptidase A</term><term>Pneumonia, Viral (diagnosis)</term><term>Pneumonia, Viral (epidemiology)</term><term>Pneumonia, Viral (therapy)</term><term>Pneumonia, Viral (transmission)</term><term>SARS Virus (genetics)</term><term>SARS Virus (pathogenicity)</term><term>Viral Envelope Proteins</term><term>Virulence</term><term>Virus Replication</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Animaux</term><term>Chine (épidémiologie)</term><term>Chiroptera</term><term>Coronavirus du syndrome respiratoire du Moyen-Orient (génétique)</term><term>Coronavirus du syndrome respiratoire du Moyen-Orient (pathogénicité)</term><term>Diarrhée (étiologie)</term><term>Fatigue (étiologie)</term><term>Femelle</term><term>Fièvre (étiologie)</term><term>Flambées de maladies</term><term>Humains</term><term>Infections à coronavirus ()</term><term>Infections à coronavirus (diagnostic)</term><term>Infections à coronavirus (transmission)</term><term>Infections à coronavirus (épidémiologie)</term><term>Mâle</term><term>Peptidyl-Dipeptidase A</term><term>Pneumopathie virale ()</term><term>Pneumopathie virale (diagnostic)</term><term>Pneumopathie virale (transmission)</term><term>Pneumopathie virale (épidémiologie)</term><term>Protéines de l'enveloppe virale</term><term>Réplication virale</term><term>Réservoirs d'agents pathogènes</term><term>Sujet âgé</term><term>Toux (étiologie)</term><term>Virulence</term><term>Virus du SRAS (génétique)</term><term>Virus du SRAS (pathogénicité)</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Peptidyl-Dipeptidase A</term><term>Viral Envelope Proteins</term></keywords><keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>China</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Coronavirus Infections</term><term>Pneumonia, Viral</term></keywords><keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr"><term>Infections à coronavirus</term><term>Pneumopathie virale</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Coronavirus Infections</term><term>Pneumonia, Viral</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Cough</term><term>Diarrhea</term><term>Fatigue</term><term>Fever</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Alphacoronavirus</term><term>Betacoronavirus</term><term>Middle East Respiratory Syndrome Coronavirus</term><term>SARS Virus</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Coronavirus du syndrome respiratoire du Moyen-Orient</term><term>Virus du SRAS</term></keywords><keywords scheme="MESH" qualifier="pathogenicity" xml:lang="en"><term>Betacoronavirus</term><term>Middle East Respiratory Syndrome Coronavirus</term><term>SARS Virus</term></keywords><keywords scheme="MESH" qualifier="pathogénicité" xml:lang="fr"><term>Coronavirus du syndrome respiratoire du Moyen-Orient</term><term>Virus du SRAS</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Coronavirus Infections</term><term>Pneumonia, Viral</term></keywords><keywords scheme="MESH" qualifier="transmission" xml:lang="en"><term>Coronavirus Infections</term><term>Pneumonia, Viral</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Chine</term><term>Infections à coronavirus</term><term>Pneumopathie virale</term></keywords><keywords scheme="MESH" qualifier="étiologie" xml:lang="fr"><term>Diarrhée</term><term>Fatigue</term><term>Fièvre</term><term>Toux</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Animals</term><term>Chiroptera</term><term>Disease Outbreaks</term><term>Disease Reservoirs</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Virulence</term><term>Virus Replication</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Animaux</term><term>Chiroptera</term><term>Femelle</term><term>Flambées de maladies</term><term>Humains</term><term>Infections à coronavirus</term><term>Mâle</term><term>Peptidyl-Dipeptidase A</term><term>Pneumopathie virale</term><term>Protéines de l'enveloppe virale</term><term>Réplication virale</term><term>Réservoirs d'agents pathogènes</term><term>Sujet âgé</term><term>Virulence</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>République populaire de Chine</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="Par1">An acute respiratory disease, caused by a novel coronavirus (SARS-CoV-2, previously known as 2019-nCoV), the coronavirus disease 2019 (COVID-19) has spread throughout China and received worldwide attention. On 30 January 2020, World Health Organization (WHO) officially declared the COVID-19 epidemic as a public health emergency of international concern. The emergence of SARS-CoV-2, since the severe acute respiratory syndrome coronavirus (SARS-CoV) in 2002 and Middle East respiratory syndrome coronavirus (MERS-CoV) in 2012, marked the third introduction of a highly pathogenic and large-scale epidemic coronavirus into the human population in the twenty-first century. As of 1 March 2020, a total of 87,137 confirmed cases globally, 79,968 confirmed in China and 7169 outside of China, with 2977 deaths (3.4%) had been reported by WHO. Meanwhile, several independent research groups have identified that SARS-CoV-2 belongs to β-coronavirus, with highly identical genome to bat coronavirus, pointing to bat as the natural host. The novel coronavirus uses the same receptor, angiotensin-converting enzyme 2 (ACE2) as that for SARS-CoV, and mainly spreads through the respiratory tract. Importantly, increasingly evidence showed sustained human-to-human transmission, along with many exported cases across the globe. The clinical symptoms of COVID-19 patients include fever, cough, fatigue and a small population of patients appeared gastrointestinal infection symptoms. The elderly and people with underlying diseases are susceptible to infection and prone to serious outcomes, which may be associated with acute respiratory distress syndrome (ARDS) and cytokine storm. Currently, there are few specific antiviral strategies, but several potent candidates of antivirals and repurposed drugs are under urgent investigation. In this review, we summarized the latest research progress of the epidemiology, pathogenesis, and clinical characteristics of COVID-19, and discussed the current treatment and scientific advancements to combat the epidemic novel coronavirus.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Lu, R" uniqKey="Lu R">R Lu</name></author><author><name sortKey="Zhao, X" uniqKey="Zhao X">X Zhao</name></author><author><name sortKey="Li, J" uniqKey="Li J">J Li</name></author><author><name sortKey="Niu, P" uniqKey="Niu P">P Niu</name></author><author><name sortKey="Yang, B" uniqKey="Yang B">B Yang</name></author><author><name sortKey="Wu, H" uniqKey="Wu H">H Wu</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Riou, J" uniqKey="Riou J">J Riou</name></author><author><name sortKey="Althaus, Cl" uniqKey="Althaus C">CL 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Yang</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Singapour</li></country></list><tree><noCountry><name sortKey="Cao, Qing Dong" sort="Cao, Qing Dong" uniqKey="Cao Q" first="Qing-Dong" last="Cao">Qing-Dong Cao</name><name sortKey="Chen, Shou Deng" sort="Chen, Shou Deng" uniqKey="Chen S" first="Shou-Deng" last="Chen">Shou-Deng Chen</name><name sortKey="Guo, Yan Rong" sort="Guo, Yan Rong" uniqKey="Guo Y" first="Yan-Rong" last="Guo">Yan-Rong Guo</name><name sortKey="Hong, Zhong Si" sort="Hong, Zhong Si" uniqKey="Hong Z" first="Zhong-Si" last="Hong">Zhong-Si Hong</name><name sortKey="Jin, Hong Jun" sort="Jin, Hong Jun" uniqKey="Jin H" first="Hong-Jun" last="Jin">Hong-Jun Jin</name><name sortKey="Tan, Yuan Yang" sort="Tan, Yuan Yang" uniqKey="Tan Y" first="Yuan-Yang" last="Tan">Yuan-Yang Tan</name><name sortKey="Yan, Yan" sort="Yan, Yan" uniqKey="Yan Y" first="Yan" last="Yan">Yan Yan</name></noCountry><country name="Singapour"><noRegion><name sortKey="Tan, Kai Sen" sort="Tan, Kai Sen" uniqKey="Tan K" first="Kai-Sen" last="Tan">Kai-Sen Tan</name></noRegion><name sortKey="Wang, De Yun" sort="Wang, De Yun" uniqKey="Wang D" first="De-Yun" last="Wang">De-Yun Wang</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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